Substance P Radioimmunoassay Using N<SUP>α</SUP>-Tyrosyl-substance P and Demonstration of the Presence of Substance P-like Immunoreactivities in Human Blood and Porcine Tissue Extracts
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چکیده
منابع مشابه
Identification of substance P precursor forms in human brain tissue.
Substance P prohormones were identified in the caudate nucleus, hypothalamus, and substantia nigra of human brain. A polypeptide fraction of acidic brain extracts was fractionated on Sephadex G-50. The lyophilized fractions were sequentially treated with trypsin and a substance P-degrading enzyme with strong preference toward the Phe7-Phe8 and Phe8-Gly9 bonds. The released substance P(1-7) frag...
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involution of the pituitary tumor, the chiasm itself may herniate into an enlarged and relatively empty sella. In some cases, this may result in traction and kinking of axons with renewed loss of function. Likewise, although the intracranial pressure diminishes following cerebrospinal fluid leaks, deterioration of visual function can also be expected when the brain, no longer buoyed by fluid, s...
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Communication between nerves and immune and inflammatory cells of the small and large intestine plays a major role in the modulation of several intestinal functions, including intestinal motility, ion transport, and mucosal permeability. Neuroimmune interactions at intestinal sites have been associated with the pathophysiology of infectious and enterotoxin-mediated diarrhea and intestinal infla...
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on the response of bone alkaline phosphatase to parathyrin. The results of a typical experiment showing percentage change in alkaline phosphatase activity compared with the hormone-free control are presented in Fig. 2(b). Tissue from 1-day-old animals was unresponsive to parathyrin, that from the 3-day-old animal showed decreased alkaline phosphatase activity and those from 5and 6-day-old anima...
متن کاملEffects of substance P and substance P antagonists on rat salivary secretion.
The intra-arterial infusion of substance P produced dose-related responses of both parotid and submandibular salivary secretion in anesthetized rats. The substance P-induced secretion in both glands was inhibited by the substance P analogues [D-Arg1, D-Trp7.9, Leu11]-substance P and [D-Arg1, D-Pro2, D-Trp7.9, Leu11]-substance P, but not by [D-Pro2, D-Trp7,9]-substance P. The profiles of protein...
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ژورنال
عنوان ژورنال: Endocrinologia Japonica
سال: 1976
ISSN: 0013-7219,2185-6370
DOI: 10.1507/endocrj1954.23.457